GABAergic Circuit Development and Its Implication for CNS Disorders
نویسندگان
چکیده
منابع مشابه
GABAergic Circuit Development and Its Implication for CNS Disorders
The function of the cerebral cortex requires the coordinated action of two major neuronal subtypes, the glutamatergic projection neurons and the GABAergic interneurons. Although , in terms of numbers, GABAergic interneurons represent a minor cell population compared to glutamater-gic neurons in the neocortex, they play an important role in modulating network dynamics of neocortical circuits. In...
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GABAergic interneurons control neuronal excitability, integration, and plasticity. Further, they regulate the generation of temporal synchrony and oscillatory behavior among networks of pyramidal neurons. Such oscillations within and across neural systems are believed to serve various complex functions, such as perception, movement initiation, and memory. Alterations in the development of GABAe...
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BACKGROUND Since the discovery of the cannabinoid receptors, numerous studies associate the endocannabinoid system with several physiological and pathological processes including cancer, appetite, fertility, memory, neuropathic and inflammatory pain, obesity, and neurodegenerative diseases. Over the last two decades, several researches have been dedicated extensively on the cannabinoid receptor...
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GABAergic interneurons are critical for the normal function and development of neural circuits, and their dysfunction is implicated in a large number of neurodevelopmental disorders. Experience and activity-dependent mechanisms play an important role in GABAergic circuit development, also recent studies involve a number of molecular players involved in the process. Emphasizing the molecular mec...
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ژورنال
عنوان ژورنال: Neural Plasticity
سال: 2011
ISSN: 2090-5904,1687-5443
DOI: 10.1155/2011/623705